Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 12/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2816632 | 0.79 | CCR2 (0.36) | EPHX1KDM4EALDH1A1SSTR4SMN1; SMN2 | |
| SCHEMBL9923566 | 0.70 | CNR1 (0.49) | EPHX1ALDH1A1SMN1; SMN2CNR1 | |
| SCHEMBL16361185 | 0.68 | ALDH1A1 (0.39) | EPHX1ALDH1A1SMN1; SMN2CNR1 | |
| SCHEMBL19961246 | 0.67 | ALDH1A1 (0.40) | EPHX1ALDH1A1SMN1; SMN2CNR1 | |
| SCHEMBL12134744 | 0.67 | ALDH1A1 (0.40) | EPHX1ALDH1A1SMN1; SMN2CNR1 | |
| SCHEMBL605200 | 0.67 | POLB (0.46) | KDM4EALDH1A1SMN1; SMN2CNR1 | |
| SCHEMBL3123112 | 0.67 | ALDH1A1 (0.42) | EPHX1ALDH1A1SMN1; SMN2CNR1EPHX2 | |
| SCHEMBL12565674 | 0.67 | ALDH1A1 (0.42) | EPHX1ALDH1A1SMN1; SMN2CNR1 | |
| SCHEMBL15402422 | 0.66 | CNR1 (0.39) | EPHX1ALDH1A1SMN1; SMN2CNR1 | |
| SCHEMBL9892338 | 0.66 | EPHX1 (0.58) | EPHX1SMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101035772-B | 2-amino-quinazoline derivatives useful as inhibitors of beta-secretase (BACE) | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-12-14 | — | — | CN | disclosed |
| CN-101035770-B | 2-amino-quinazoline derivatives useful as inhibitors of beta-secretase (BACE) | JANSSEN PHARMACEUTICA NV | 2011-02-23 | — | — | CN | disclosed |
| CN-101035770-A | Novel 2-amino-quinazoline derivatives useful as inhibitors of beta-secretase (BACE) | JANSSEN PHARMACEUTICA NV (BE) | 2007-09-12 | — | — | CN | disclosed |
| CN-101035771-A | 2-amino-quinazoline derivatives useful as inhibitors of beta-secretase (BACE) | JANSSEN PHARMACEUTICA NV (BE) | 2007-09-12 | — | — | CN | disclosed |