Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28185274 | 0.96 | CA1 (0.42) | CA1CA2CA9 | |
| Bicarbonate SCHEMBL2217045 | 0.95 | CA1 (0.50) | CA1CA2CA9FFAR3ALDH1A1 | |
| SCHEMBL3141792 | 0.95 | — | — | |
| SCHEMBL5836397 | 0.95 | CA1 (0.36) | CA1CA2CA9FFAR3ALDH1A1 | |
| SCHEMBL28869253 | 0.91 | — | — | |
| Bicarbonate SCHEMBL28097261 | 0.91 | CA1 (0.46) | CA1CA2CA9FFAR3ALDH1A1 | |
| Water SCHEMBL991250 | 0.91 | CA1 (0.33) | CA1CA2CA9FFAR3ALDH1A1 | |
| SCHEMBL21694771 | 0.91 | — | — | |
| SCHEMBL28135356 | 0.91 | CA1 (0.33) | CA1CA2CA9FFAR3ALDH1A1 | |
| SCHEMBL7793 | 0.91 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101886182-A | Synthesized chemical powder capable of purifying tin melt liquid and application fixture and use method thereof | LIHAN APPLIC TECHNOLOGY CO LTD | 2010-11-17 | — | — | CN | disclosed |
| CN-101065366-A | Dibenzyl amine compounds and derivatives | PFIZER PROD INC (US) | 2007-10-31 | — | — | CN | disclosed |