Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | STAT1 | P42224 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.37 |
| ▸ | CCR4 | P51679 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | TYR | P14679 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | DNM2 | P50570 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28154659 | 0.78 | NPC1 (0.56) | NPC1ALDH1A1MAPTSTAT1RAB9A | |
| SCHEMBL9836855 | 0.76 | NPC1 (0.55) | NPC1ALDH1A1MAPTSTAT1RAB9A | |
| SCHEMBL10466181 | 0.75 | NPC1 (0.54) | NPC1ALDH1A1MAPTSTAT1RAB9A | |
| SCHEMBL14081441 | 0.74 | SMN1; SMN2 (0.44) | NPC1ALDH1A1MAPTRAB9ACCR4 | |
| SCHEMBL18398871 | 0.73 | NPC1 (0.51) | NPC1ALDH1A1MAPTSTAT1RAB9A | |
| SCHEMBL27705839 | 0.71 | SMN1; SMN2 (0.53) | NPC1ALDH1A1MAPTSTAT1RAB9A | |
| SCHEMBL3507053 | 0.71 | NPC1 (0.49) | NPC1ALDH1A1MAPTSTAT1RAB9A | |
| SCHEMBL11498389 | 0.71 | PDE5A (0.50) | NPC1ALDH1A1MAPTSTAT1RAB9A | |
| SCHEMBL4099165 | 0.70 | RAB9A (0.59) | NPC1ALDH1A1MAPTSTAT1RAB9A | |
| SCHEMBL15080346 | 0.70 | MAPT (0.44) | NPC1ALDH1A1MAPTSTAT1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128461-B | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI | 2010-12-22 | — | — | CN | disclosed |
| CN-101128461-A | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI (US) | 2008-02-20 | — | — | CN | disclosed |