Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | STAT1 | P42224 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.37 |
| ▸ | TYR | P14679 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28154659 | 0.85 | NPC1 (0.56) | NPC1MAPTRAB9AALDH1A1STAT1 | |
| SCHEMBL10466181 | 0.83 | NPC1 (0.54) | NPC1MAPTRAB9AALDH1A1STAT1 | |
| SCHEMBL4099165 | 0.78 | RAB9A (0.59) | NPC1MAPTRAB9AALDH1A1STAT1 | |
| SCHEMBL11498389 | 0.78 | PDE5A (0.50) | NPC1MAPTRAB9AALDH1A1STAT1 | |
| SCHEMBL3507053 | 0.78 | NPC1 (0.49) | NPC1MAPTRAB9AALDH1A1STAT1 | |
| SCHEMBL24590345 | 0.77 | RAB9A (0.57) | NPC1MAPTRAB9AALDH1A1STAT1 | |
| SCHEMBL27686804 | 0.76 | NPC1 (0.47) | NPC1MAPTRAB9AALDH1A1STAT1 | |
| SCHEMBL4685246 | 0.75 | PDE5A (0.70) | NPC1MAPTRAB9AALDH1A1KMT2A | |
| SCHEMBL1860420 | 0.73 | — | — | |
| SCHEMBL13105682 | 0.73 | NPC1 (0.43) | NPC1MAPTRAB9AALDH1A1STAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0224919-B1 | NEW THIAZOLE COMPOUNDS, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-08-14 | — | — | EP | disclosed |
| US-4742057-A | Antiallergic thiazole compounds | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-05-03 | — | — | US | disclosed |
| EP-0224919-A2 | New thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-06-10 | — | — | EP | disclosed |