Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.40 |
| ▸ | EIF2AK2 | P19525 | 3/20 | 0.39 |
| ▸ | TERT | O14746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27708226 | 0.94 | MGLL (0.39) | IKBKBCHUKIKBKGEIF2AK2MKNK1 | |
| SCHEMBL28770004 | 0.88 | IKBKB (0.39) | IKBKBCHUKIKBKGSYK | |
| SCHEMBL27688651 | 0.86 | IKBKB (0.39) | IKBKBCHUKIKBKGSYK | |
| SCHEMBL2980745 | 0.85 | MAPK3 (0.44) | IKBKBCHUKIKBKGEIF2AK2TERT | |
| SCHEMBL27688628 | 0.85 | IKBKB (0.45) | IKBKBCHUKIKBKGLMNARAB9A | |
| SCHEMBL27708383 | 0.85 | IKBKB (0.38) | IKBKBCHUKIKBKGSYK | |
| SCHEMBL27688650 | 0.85 | IKBKB (0.37) | IKBKBCHUKIKBKGTSHRLMNA | |
| SCHEMBL27688661 | 0.85 | PDGFRB (0.45) | IKBKBCHUKIKBKGSYK | |
| SCHEMBL27708347 | 0.84 | IKBKB (0.41) | IKBKBCHUKIKBKGNPY5RSYK | |
| SCHEMBL27688663 | 0.84 | IKBKB (0.41) | IKBKBCHUKIKBKGSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101115749-B | Aminopyrimidine compounds and methods of use | AMGEN INC | 2011-06-22 | — | — | CN | disclosed |
| CN-101115749-A | Aminopyrimidine compounds and methods of use | AMGEN INC (US) | 2008-01-30 | — | — | CN | disclosed |