Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.30 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.66 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.66 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.66 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL730717 | 0.98 | GNAI3 (0.68) | GNAI3GNAO1GNAI1HRH4HSD17B10 | |
| SCHEMBL4723776 | 0.84 | — | — | |
| SCHEMBL4974361 | 0.84 | GNAO1 (0.81) | GNAI3GNAO1GNAI1HRH4SIGMAR1 | |
| Bromide SCHEMBL27708672 | 0.84 | GNAO1 (0.93) | GNAI3GNAO1GNAI1HRH4 | |
| SCHEMBL3260063 | 0.83 | GNAO1 (0.92) | GNAI3GNAO1GNAI1HRH4SIGMAR1 | |
| Bromide SCHEMBL28768421 | 0.81 | GNAI3 (0.53) | GNAI3GNAO1GNAI1 | |
| SCHEMBL27389928 | 0.81 | GNAO1 (0.96) | GNAI3GNAO1GNAI1HRH4 | |
| SCHEMBL8778709 | 0.80 | GNAI3 (0.45) | GNAI3GNAO1GNAI1 | |
| SCHEMBL20000752 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL5370724 | 0.79 | GNAO1 (1.00) | GNAI3GNAO1GNAI1HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100463720-C | Phase-transferring catalyst containing dinaphthalene chiral double-spiral quaternary ammonium and its production | UNIV TIANJIN (CN) | 2009-02-25 | — | — | CN | disclosed |
| CN-101073780-A | Phase-transferring catalyst containing dinaphthalene chiral double-spiral quaternary ammonium and its production | UNIV TIANJIN (CN) | 2007-11-21 | — | — | CN | disclosed |