Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 4/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27693261 | 0.92 | CXCR2 (0.51) | CXCR2PRMT5WDR77KMT2ARAB9A | |
| SCHEMBL27712958 | 0.90 | CXCR2 (0.57) | CXCR2KMT2ARAB9AALDH1A1MEN1 | |
| SCHEMBL27693224 | 0.90 | CXCR2 (0.45) | CXCR2KMT2ARAB9AALDH1A1MEN1 | |
| SCHEMBL27713046 | 0.88 | CXCR2 (0.57) | CXCR2ALDH1A1NPSR1GAAMAPT | |
| SCHEMBL27693429 | 0.86 | CXCR2 (0.49) | CXCR2NPC1MAPT | |
| SCHEMBL27693236 | 0.85 | CXCR2 (0.53) | CXCR2RAB9AALDH1A1NPC1KDM4E | |
| SCHEMBL27693220 | 0.85 | CXCR2 (0.46) | CXCR2KMT2ARAB9AMEN1 | |
| SCHEMBL485602 | 0.85 | CXCR2 (0.63) | CXCR2PRMT5WDR77KMT2ARAB9A | |
| SCHEMBL28770785 | 0.83 | CXCR2 (0.42) | CXCR2ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL27693207 | 0.82 | ALOX5AP (0.47) | CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101094830-A | Fused bicyclic carboxamide derivatives for use as CXCR2 inhibitors in the treatment of inflammation | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-12-26 | — | — | CN | claimed |
| CN-101094830-A | Fused bicyclic carboxamide derivatives for use as CXCR2 inhibitors in the treatment of inflammation | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-12-26 | — | — | CN | disclosed |