Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 6/20 | 0.53 |
| ▸ | PTPRZ1 | P23471 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | PDE2A | O00408 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.33 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27713046 | 0.88 | CXCR2 (0.57) | CXCR2MAPTALDH1A1GAASMN1; SMN2 | |
| SCHEMBL27693210 | 0.87 | CXCR2 (0.57) | CXCR2PTPRZ1PDE2AKCNK2KCNK10 | |
| SCHEMBL27712958 | 0.87 | CXCR2 (0.57) | CXCR2MAPTALDH1A1GAALMNA | |
| SCHEMBL27693261 | 0.87 | CXCR2 (0.51) | CXCR2MAPTALDH1A1GAASMN1; SMN2 | |
| SCHEMBL485653 | 0.87 | CXCR2 (0.67) | CXCR2PTPRZ1MAPTALDH1A1GAA | |
| SCHEMBL27693429 | 0.87 | CXCR2 (0.49) | CXCR2MAPTNPC1 | |
| SCHEMBL27693228 | 0.85 | CXCR2 (0.46) | CXCR2MAPTALDH1A1GAAPTPN1 | |
| SCHEMBL485250 | 0.85 | CXCR2 (0.67) | CXCR2PTPRZ1MAPTALDH1A1GAA | |
| SCHEMBL15911879 | 0.83 | CXCR2 (0.52) | CXCR2PTPRZ1MAPTALDH1A1GAA | |
| SCHEMBL27693224 | 0.83 | CXCR2 (0.45) | CXCR2MAPTALDH1A1GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101094830-A | Fused bicyclic carboxamide derivatives for use as CXCR2 inhibitors in the treatment of inflammation | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-12-26 | — | — | CN | claimed |
| CN-101094830-A | Fused bicyclic carboxamide derivatives for use as CXCR2 inhibitors in the treatment of inflammation | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-12-26 | — | — | CN | disclosed |