Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.47 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.47 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.47 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | KDM4A | O75164 | 1/20 | 0.47 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27693283 | 0.90 | LDHA (0.51) | LDHAPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL485239 | 0.81 | KDM4E (0.63) | LDHAP2RX1P2RX3P2RX4P2RX7 | |
| SCHEMBL10719823 | 0.81 | LDHA (0.59) | LDHAP2RX1P2RX3P2RX4P2RX7 | |
| SCHEMBL27693288 | 0.81 | CXCR2 (0.54) | LDHAPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL486080 | 0.80 | KMT2A (0.47) | LDHAPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL27693316 | 0.76 | CXCR2 (0.44) | LDHAMEN1KMT2AKDM4EMAPT | |
| SCHEMBL27693310 | 0.74 | CYP1A1 (0.55) | LDHAPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL484914 | 0.74 | KMT2A (0.51) | LDHAP2RX1P2RX3P2RX4P2RX7 | |
| SCHEMBL27693304 | 0.72 | KDM4E (0.52) | MEN1KMT2AKDM4EMAPTHTT | |
| SCHEMBL27693281 | 0.72 | LDHA (0.49) | LDHAPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101094830-A | Fused bicyclic carboxamide derivatives for use as CXCR2 inhibitors in the treatment of inflammation | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-12-26 | — | — | CN | disclosed |