Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 11/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.37 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | ATIC | P31939 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27693285 | 0.85 | KDM4E (0.73) | KDM4EPOLBAPEX1MCL1HSD17B10 | |
| SCHEMBL485751 | 0.84 | KDM4E (0.71) | KDM4EPOLBAPEX1MCL1HSD17B10 | |
| SCHEMBL28766910 | 0.82 | KDM4E (0.52) | KDM4EPOLBAPEX1MCL1HSD17B10 | |
| SCHEMBL27693283 | 0.80 | LDHA (0.51) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL27713027 | 0.78 | KDM4E (0.49) | KDM4EPOLBAPEX1MCL1HSD17B10 | |
| SCHEMBL485613 | 0.77 | KDM4E (0.54) | KDM4EPOLBAPEX1MCL1CYP2C9 | |
| SCHEMBL27693316 | 0.73 | CXCR2 (0.44) | KDM4EPOLBMEN1MAPTKMT2A | |
| SCHEMBL484864 | 0.73 | KDM4E (0.44) | KDM4EPOLBAPEX1MCL1CYP2C9 | |
| SCHEMBL17262485 | 0.73 | HNF4A (0.41) | KDM4EPOLBMAPTALDH1A1 | |
| SCHEMBL484865 | 0.73 | KDM4E (0.44) | KDM4EPOLBAPEX1MCL1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101094830-A | Fused bicyclic carboxamide derivatives for use as CXCR2 inhibitors in the treatment of inflammation | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-12-26 | — | — | CN | disclosed |