Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 5/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.36 |
| ▸ | ELANE | P08246 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27817033 | 1.00 | MIF (0.36) | MIFESR1ESR2ELANEMAPK1 | |
| SCHEMBL27696365 | 1.00 | MIF (0.36) | MIFESR1ESR2ELANEMAPK1 | |
| SCHEMBL5414409 | 0.87 | MIF (0.40) | MIFESR1ESR2ELANEMAPK1 | |
| SCHEMBL9995953 | 0.87 | MIF (0.40) | MIFESR1ESR2ELANEMAPK1 | |
| SCHEMBL5414405 | 0.87 | MIF (0.40) | MIFESR1ESR2ELANEMAPK1 | |
| SCHEMBL27791305 | 0.86 | APP (0.35) | ELANECTSSCTSKADRB2ADRB1 | |
| SCHEMBL27636817 | 0.86 | ATM (0.41) | ELANEMAPK1CTSSCTSKKMT2A | |
| SCHEMBL6606388 | 0.86 | ATM (0.41) | ELANEMAPK1CTSSCTSKKMT2A | |
| SCHEMBL1925699 | 0.86 | ATM (0.41) | ELANEMAPK1CTSSCTSKKMT2A | |
| SCHEMBL1963341 | 0.84 | ALDH1A1 (0.43) | ELANECTSSCTSKKMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102686575-A | Modulators of G-protein coupled receptor 88 | BRISTOL MYERS SQUIBB CO | 2012-09-19 | — | — | CN | disclosed |
| CN-101389609-B | Hydantoin-based kinase inhibitors | HOFFMANN LA ROCHE | 2012-01-11 | — | — | CN | disclosed |
| CN-101896469-A | Substituted hydantoins as MEK kinase inhibitors | HOFFMANN LA ROCHE | 2010-11-24 | — | — | CN | disclosed |
| CN-101778839-A | substituted hydantoins | HOFFMANN LA ROCHE | 2010-07-14 | — | — | CN | disclosed |
| CN-101023079-B | Substituted hydantoins for the treatment of cancer | HOFFMANN LA ROCHE | 2010-05-05 | — | — | CN | disclosed |
| CN-101389609-A | Hydantoin-based kinase inhibitors | HOFFMANN LA ROCHE (CH) | 2009-03-18 | — | — | CN | disclosed |
| CN-101023079-A | Substituted hydantoins for the treatment of cancer | HOFFMANN LA ROCHE (CH) | 2007-08-22 | — | — | CN | disclosed |
| CN-101006085-A | Substituted hydantoins | HOFFMANN LA ROCHE (CH) | 2007-07-25 | — | — | CN | disclosed |