Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.46 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | SMO | Q99835 | 1/20 | 0.44 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27920306 | 0.86 | HRH3 (0.46) | HRH3PANK3 | |
| SCHEMBL27846042 | 0.84 | HRH3 (0.62) | KDM4EMAPTHRH3 | |
| SCHEMBL27846068 | 0.84 | HRH3 (0.60) | HRH3 | |
| SCHEMBL28789456 | 0.83 | PANK3 (0.50) | HRH3GPR119PANK3 | |
| SCHEMBL27551999 | 0.81 | TRPV1 (0.47) | HRH3GPR119SMO | |
| SCHEMBL23300743 | 0.80 | HRH3 (0.51) | KDM4EMAPTHRH3DEGS1GPR119 | |
| SCHEMBL27913158 | 0.80 | GPR119 (0.56) | HRH3GPR119SMO | |
| SCHEMBL27665053 | 0.80 | HTR3E (0.54) | HRH3SMO | |
| SCHEMBL27718555 | 0.80 | CHRM4 (0.45) | HRH3 | |
| SCHEMBL27940101 | 0.80 | HRH3 (0.47) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101137628-A | Non-anilinic derivatives of isothiazol-3(2h)-one 1,1-dioxides as liver x receptor modulators | ASTRAZENECA AB (SE) | 2008-03-05 | — | — | CN | disclosed |