Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.40 |
| ▸ | XIAP | P98170 | 5/20 | 0.38 |
| ▸ | BIRC2 | Q13490 | 5/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MYC | P01106 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4805051 | 0.85 | HTT (0.45) | HTTXIAPBIRC2HTR6L3MBTL1 | |
| SCHEMBL4805065 | 0.85 | HTT (0.45) | HTTXIAPBIRC2HTR6L3MBTL1 | |
| SCHEMBL27679127 | 0.74 | GHSR (0.37) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL4933480 | 0.72 | HTT (0.51) | HTTHTR6ALDH1A1KDM4EMEN1 | |
| SCHEMBL4933476 | 0.72 | HTT (0.51) | HTTHTR6ALDH1A1KDM4EMEN1 | |
| SCHEMBL18163352 | 0.71 | HCRTR1 (0.47) | CRHR1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL27679132 | 0.70 | KMT2A (0.48) | HTTALDH1A1KMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL29712843 | 0.68 | ALDH1A1 (0.69) | HTTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL1144066 | 0.68 | ALDH1A1 (0.69) | HTTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL6331423 | 0.67 | HSP90AB1 (0.67) | HTTALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101031564-A | Piperazine derivatives for the treatment of gastrointestinal disorders | GLAXO GROUP LTD (GB) | 2007-09-05 | — | — | CN | disclosed |