Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Niacinamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F7 | P08709 | 1/20 | 0.79 |
| ▸ | F3 | P13726 | 1/20 | 0.79 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.79 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.79 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.79 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.79 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.79 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.79 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.79 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | APP | P05067 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.58 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.58 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Niacinamide SCHEMBL27641063 | 1.00 | F7 (0.79) | F7F3SARM1SIRT2SIRT6 | |
| Niacinamide SCHEMBL29204086 | 1.00 | F7 (0.79) | F7F3SARM1SIRT2SIRT6 | |
| Niacinamide SCHEMBL19876218 | 1.00 | F7 (0.79) | F7F3SARM1SIRT2SIRT6 | |
| Niacinamide SCHEMBL675207 | 0.91 | F7 (0.96) | F7F3SARM1SIRT2SIRT6 | |
| Niacinamide SCHEMBL460466 | 0.89 | F7 (1.00) | F7F3SARM1SIRT2SIRT6 | |
| Niacinamide SCHEMBL29624874 | 0.89 | — | — | |
| Niacinamide SCHEMBL19978192 | 0.89 | — | — | |
| Niacinamide SCHEMBL2926 | 0.89 | — | — | |
| Niacinamide SCHEMBL25379882 | 0.88 | F7 (0.76) | F7F3SARM1SIRT2SIRT6 | |
| Niacinamide SCHEMBL30978150 | 0.88 | F7 (0.76) | F7F3SARM1SIRT2SIRT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101031299-A | Thienopyridinone compounds and methods of treatment | EPIX DELAWARE INC (US) | 2007-09-05 | — | — | CN | claimed |
| CN-117462690-B | Pharmaceutical composition and application thereof | 中南林业科技大学 | 2025-03-21 | — | — | CN | disclosed |
| CN-117462690-A | Pharmaceutical composition and application thereof | 中南林业科技大学 | 2024-01-30 | — | — | CN | disclosed |
| CN-101031299-A | Thienopyridinone compounds and methods of treatment | EPIX DELAWARE INC (US) | 2007-09-05 | — | — | CN | disclosed |