Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.53 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.49 |
| ▸ | ESR1 | P03372 | 2/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.49 |
| ▸ | TACR2 | P21452 | 2/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SHBG | P04278 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11422307 | 0.98 | KAT8 (0.55) | KAT8PPARAHSD17B10TSHRPTGS2 | |
| SCHEMBL10343234 | 0.98 | KAT8 (0.55) | KAT8PPARAHSD17B10TSHRPTGS2 | |
| SCHEMBL3967357 | 0.98 | KAT8 (0.55) | KAT8PPARAHSD17B10TSHRPTGS2 | |
| SCHEMBL11127882 | 0.95 | NPC1 (0.50) | KAT8PPARAHSD17B10TSHRPTGS2 | |
| SCHEMBL11321401 | 0.88 | CNR1 (0.58) | HSD17B10TSHRCYP3A4KDM4EHIF1A | |
| SCHEMBL11660136 | 0.88 | HSD17B10 (0.59) | KAT8HSD17B10TSHRPTGS2ESR1 | |
| SCHEMBL9226224 | 0.86 | HSD17B10 (0.61) | KAT8HSD17B10TSHRPTGS2ESR1 | |
| SCHEMBL31220615 | 0.85 | PPARA (0.55) | KAT8PPARAHSD17B10TSHRPTGS2 | |
| SCHEMBL28826019 | 0.84 | HSD17B10 (0.53) | KAT8PPARAHSD17B10TSHRPTGS2 | |
| SCHEMBL17818519 | 0.83 | HSD17B10 (0.56) | KAT8PPARAHSD17B10TSHRPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10005777-B2 | Protein kinase C inhibitors and uses thereof | RIGEL PHARMACEUTICALS, INC. (US) | 2018-06-26 | — | — | US | disclosed |
| US-20180030050-A1 | Protein Kinase C Inhibitors and Uses Thereof | MIDCAP FINANCIAL TRUST | 2018-02-01 | — | — | US | disclosed |
| US-8848158-B2 | Liquid crystal display device and associated liquid crystal media for use in the same | GENTEX CORPORATION (US) | 2014-09-30 | — | — | US | disclosed |
| US-7803285-B2 | Liquid crystal display device and associated liquid crystal media for use in the same | GENTEX CORPORATION (US) | 2010-09-28 | — | — | US | disclosed |
| US-20100097563-A1 | Liquid crystal display device and associated liquid crystal media for use in the same | GENTEX CORPORATION | 2010-04-22 | — | — | US | disclosed |
| US-20100040804-A1 | Liquid crystal display device and associated liquid crystal media for use in the same | GENTEX CORPORATION | 2010-02-18 | — | — | US | disclosed |
| US-4287085-A | (2'-Cyano-4'-alkylphenyl)-3-cyano-4-alkoxybenzoates and liquid crystal composition including same | KABUSHIKI KAISHA SUWA SEIKOSHA (JP) | 1981-09-01 | — | — | US | disclosed |
| US-4279771-A | (2'-Cyano-4'-n-alkyl)phenyl-3-chloro-4-n-alkoxy benzoates and liquid crystal compositions thereof | KABUSHIKI KAISHA SUWA SEIKOSHA (JP) | 1981-07-21 | — | — | US | disclosed |
| US-4073742-A | Cyano-substituted biphenyl compounds and liquid crystalline dielectrics containing the same | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) | 1978-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10005777-B2 | Protein kinase C inhibitors and uses thereof | PRKCH, PRKCA, PRKCB | KAT8 1936/4885PPARA 2553/4885HSD17B10 2599/4885 |
| US-20180030050-A1 | Protein Kinase C Inhibitors and Uses Thereof | PRKCH, PRKCA, PRKCB | KAT8 1936/4885PPARA 2553/4885HSD17B10 2599/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.