Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | SCD | O00767 | 2/20 | 0.39 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27698606 | 0.91 | MEN1 (0.46) | PTGS1PTGS2POLBTSHRNPSR1 | |
| SCHEMBL27698639 | 0.89 | KMT2A (0.46) | NPSR1MAPTALDH1A1PRKAA2TP53 | |
| SCHEMBL27679665 | 0.89 | LMNA (0.46) | POLBTSHRNPSR1MAPTALDH1A1 | |
| SCHEMBL27698653 | 0.88 | PTGS1 (0.42) | PTGS1PTGS2POLBTSHRNPSR1 | |
| SCHEMBL27861832 | 0.85 | SMN1; SMN2 (0.37) | PTGS1PTGS2POLBTSHRNPSR1 | |
| SCHEMBL2186625 | 0.84 | MAPT (0.56) | PTGS1PTGS2POLBTSHRNPSR1 | |
| SCHEMBL27698603 | 0.83 | HTR1F (0.39) | PRKAA2MAPK1 | |
| SCHEMBL28764306 | 0.82 | NPSR1 (0.49) | TSHRNPSR1MAPTALDH1A1TP53 | |
| SCHEMBL27679765 | 0.81 | LMNA (0.44) | POLBTSHRNPSR1MAPTALDH1A1 | |
| SCHEMBL27698608 | 0.80 | MEN1 (0.45) | PTGS1PTGS2POLBTSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101031567-B | Novel heterocyclic NF-kB inhibitors | 4SC Corp.,Ltd. (DE) | 2011-12-21 | — | — | CN | disclosed |
| CN-101031567-A | Novel heterocyclic NF-kB inhibitors | 4SC AG (DE) | 2007-09-05 | — | — | CN | disclosed |