Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of 2-Pyrrolidone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.75 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.64 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CA5A | P35218 | 1/20 | 0.30 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Pyrrolidone SCHEMBL17061486 | 1.00 | OR51E2 (0.75) | OR51E2CRBNFKBP5KDM4EGAA | |
| 2-Pyrrolidone SCHEMBL4966601 | 0.98 | OR51E2 (0.71) | OR51E2CRBNFKBP5KDM4EGAA | |
| Sulfuric Acid SCHEMBL30278662 | 0.93 | CRBN (0.76) | OR51E2CRBNFKBP5KDM4EGAA | |
| 2-Pyrrolidone SCHEMBL8962584 | 0.91 | OR51E2 (0.68) | OR51E2CRBNFKBP5KDM4EGAA | |
| 2-Pyrrolidone SCHEMBL8962586 | 0.91 | OR51E2 (0.68) | OR51E2CRBNFKBP5KDM4EGAA | |
| 2-Pyrrolidone SCHEMBL27503412 | 0.91 | OR51E2 (0.68) | OR51E2CRBNFKBP5KDM4EGAA | |
| Sulfuric Acid SCHEMBL28455727 | 0.91 | CRBN (0.73) | OR51E2CRBNFKBP5KDM4EGAA | |
| Caprolactam SCHEMBL1521129 | 0.91 | CRBN (0.73) | OR51E2CRBNFKBP5KDM4EGAA | |
| 2-Pyrrolidone SCHEMBL28474712 | 0.89 | OR51E2 (0.60) | OR51E2CRBNFKBP5KDM4EGAA | |
| Caprolactam SCHEMBL27970597 | 0.89 | CRBN (0.70) | OR51E2CRBNFKBP5KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109575206-A | A method of using pyroles acidic ion liquid as catalyst preparation phenolic resin | 常州大学 | 2019-04-05 | — | — | CN | claimed |
| CN-108554447-A | A kind of phenols butylation catalyst and butylation method | 陕西巴斯腾科技有限公司 | 2018-09-21 | — | — | CN | claimed |
| CN-108484365-A | A kind of separation method of 3-Isopropylphenol and australol | 陕西巴斯腾科技有限公司 | 2018-09-04 | — | — | CN | claimed |
| CN-108484364-A | A kind of separation method of m-ethylphenol and paraethyl phenol | 陕西巴斯腾科技有限公司 | 2018-09-04 | — | — | CN | claimed |
| CN-103483190-B | A kind of method of the production of alkyl carbonate | 安徽时联特种溶剂股份有限公司 | 2018-08-21 | — | — | CN | claimed |
| CN-107216231-A | A kind of purification process of electron level n-hexane | 太仓沪试试剂有限公司 | 2017-09-29 | — | — | CN | claimed |
| CN-106565618-A | Catalyst ligand for directly synthesizing lubricating oil base oil from alpha-olefin, and coordination compound thereof, and preparation methods and applications of catalyst ligand and coordination compound | 常州大学 | 2017-04-19 | — | — | CN | claimed |
| CN-106315623-A | Synthetic method of ammonium sulfate | 太仓市新星轻工助剂厂 | 2017-01-11 | — | — | CN | claimed |
| CN-106278783-A | A kind of purification process of normal hexane | 太仓沪试试剂有限公司 | 2017-01-04 | — | — | CN | claimed |
| CN-106317363-B | Solid-solid phase transition material and its preparation method and application | 深圳市汉华热管理科技有限公司 | 2019-10-25 | — | — | CN | disclosed |
| CN-107188847-B | One kind catalyzing and synthesizing 4- aryl-N- phenyl-Isosorbide-5-Nitrae, the method for 5,6,7,8- hexahydro quinoline -3- amides | 马鞍山市泰博化工科技有限公司 | 2019-09-10 | — | — | CN | disclosed |
| CN-109575206-A | A method of using pyroles acidic ion liquid as catalyst preparation phenolic resin | 常州大学 | 2019-04-05 | — | — | CN | disclosed |
| CN-106698406-B | A kind of technique that electrochemistry prepares graphene | 德阳烯碳科技有限公司 | 2019-03-15 | — | — | CN | disclosed |
| CN-108554447-A | A kind of phenols butylation catalyst and butylation method | 陕西巴斯腾科技有限公司 | 2018-09-21 | — | — | CN | disclosed |
| CN-106317363-A | Solid-solid phase change material as well as preparation method and application thereof | 深圳市汉华热管理科技有限公司 | 2017-01-11 | — | — | CN | disclosed |
| CN-106315623-A | Synthetic method of ammonium sulfate | 太仓市新星轻工助剂厂 | 2017-01-11 | — | — | CN | disclosed |
| CN-106278783-A | A kind of purification process of normal hexane | 太仓沪试试剂有限公司 | 2017-01-04 | — | — | CN | disclosed |
| CN-103752340-B | Functionalized acidic ionic liquid application in the esterification reaction | JIANG University OF TECHNOLOGY (CN) | 2016-11-30 | — | — | CN | disclosed |
| CN-103752340-A | Applications of acidic functionalized ion liquid in esterification reaction | UNIV ZHEJIANG TECHNOLOGY | 2014-04-30 | — | — | CN | disclosed |
| CN-101147877-A | Method for preparing supported ion liquid and its application in catalytic hydroxy acid esterifying | UNIV GUANGDONG TECHNOLOGY (CN) | 2008-03-26 | — | — | CN | disclosed |