Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 17/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | HSD11B2 | P80365 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3174558 | 0.77 | HSD11B1 (0.44) | HSD11B1EPHX2ALDH1A1 | |
| SCHEMBL3181151 | 0.76 | HSD11B1 (0.38) | HSD11B1EPHX2CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1223425 | 0.66 | HSD11B1 (0.64) | HSD11B1HSD11B2ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL13211223 | 0.65 | HSD11B1 (0.65) | HSD11B1EPHX2HSD11B2 | |
| SCHEMBL25269622 | 0.63 | FFAR3 (0.44) | EPHX2ALDH1A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL7018317 | 0.63 | FFAR3 (0.44) | EPHX2ALDH1A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL25268918 | 0.63 | FFAR3 (0.44) | EPHX2ALDH1A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL4100277 | 0.62 | HSD11B1 (0.96) | HSD11B1EPHX2 | |
| SCHEMBL1222842 | 0.61 | HSD11B1 (1.00) | HSD11B1HSD11B2CYP1A2 | |
| SCHEMBL4099349 | 0.60 | HSD11B1 (1.00) | HSD11B1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102816081-A | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme | ABBOTT LAB | 2012-12-12 | — | — | CN | disclosed |
| CN-101142172-A | Inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1 enzyme | ABBOTT LAB (US) | 2008-03-12 | — | — | CN | disclosed |