Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN5 | P54829 | 4/20 | 0.44 |
| ▸ | KIF11 | P52732 | 5/20 | 0.36 |
| ▸ | PDE2A | O00408 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.35 |
| ▸ | SMO | Q99835 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28244471 | 0.79 | KIF11 (0.38) | KIF11CYP2C9 | |
| SCHEMBL14087362 | 0.78 | PTPN5 (0.59) | PTPN5KIF11PDE2ACYP2D6CYP2C9 | |
| SCHEMBL1979146 | 0.77 | KIF11 (0.59) | KIF11 | |
| SCHEMBL28540008 | 0.77 | TRPV1 (0.41) | KIF11 | |
| SCHEMBL28436016 | 0.77 | KIF11 (0.54) | PTPN5KIF11 | |
| SCHEMBL84043 | 0.75 | PDE2A (0.53) | PTPN5KIF11PDE2ACYP2D6CYP2C9 | |
| SCHEMBL8123180 | 0.75 | NOTUM (0.34) | PTPN5KIF11 | |
| SCHEMBL16958492 | 0.74 | KIF11 (0.35) | PTPN5KIF11PDE2A | |
| Ammonia Solution, Strong SCHEMBL27642816 | 0.73 | PDE2A (0.52) | PTPN5KIF11PDE2ACYP2D6CYP2C9 | |
| SCHEMBL18334808 | 0.72 | PTPN5 (0.37) | PTPN5AKR1C3AKR1C2SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101044115-A | Piperidines and related compounds for treatment of alzheimer's disease | MERCK SHARP & DOHME (GB) | 2007-09-26 | — | — | CN | disclosed |