Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | USP7 | Q93009 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19721378 | 0.81 | KMT2A (0.47) | ALDH1A1HTTKMT2AMEN1POLB | |
| SCHEMBL15359055 | 0.77 | USP7 (0.60) | HTTKMT2AMEN1POLBMAPT | |
| SCHEMBL2226848 | 0.77 | FYN (0.54) | HTTKMT2ACDK8USP7DYRK1A | |
| SCHEMBL12516853 | 0.77 | ADORA1 (0.49) | ALDH1A1HTTKMT2AMEN1RAB9A | |
| SCHEMBL29857829 | 0.77 | CHEK2 (0.53) | HTTKMT2AMEN1MAPTUSP7 | |
| SCHEMBL26917180 | 0.77 | CHEK2 (0.53) | HTTKMT2AMEN1MAPTUSP7 | |
| SCHEMBL29857982 | 0.77 | ADORA1 (0.49) | ALDH1A1HTTKMT2AMEN1RAB9A | |
| SCHEMBL27699378 | 0.77 | FYN (0.49) | HTTKMT2AUSP7MAP4K4CHEK2 | |
| SCHEMBL29858039 | 0.74 | MAP4K4 (0.50) | AXLDYRK1ADYRK3MAP4K4FYN | |
| SCHEMBL26916986 | 0.74 | MAP4K4 (0.50) | AXLDYRK1ADYRK3MAP4K4FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101027302-B | Pyrrolo-pyridine kinase modulators | SGX PHARMACEUTICALS INC | 2011-05-11 | — | — | CN | disclosed |
| CN-101027302-A | Pyrrolo-pyridine kinase modulators | SGX PHARMACEUTICALS INC (US) | 2007-08-29 | — | — | CN | disclosed |