Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.41 |
| ▸ | RXRA | P19793 | 2/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.34 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.33 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 4/20 | 0.32 |
| ▸ | PPARA | Q07869 | 2/20 | 0.32 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.31 |
| ▸ | HNF4A | P41235 | 1/20 | 0.31 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.31 |
| ▸ | GLP1R | P43220 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2771301 | 0.93 | NR1H4 (0.43) | NR1H4LNPEPP2RY1PPARDPPARA | |
| SCHEMBL2771573 | 0.92 | NR1H4 (0.40) | NR1H4LNPEPP2RY1PPARDPPARA | |
| SCHEMBL2775274 | 0.88 | NR1H4 (0.40) | NR1H4LNPEPP2RY1PPARDPPARA | |
| SCHEMBL2770877 | 0.85 | NR1H4 (0.42) | NR1H4RXRARXRBRXRGLNPEP | |
| SCHEMBL2771604 | 0.83 | NR1H4 (0.59) | NR1H4MRGPRX4 | |
| SCHEMBL2773384 | 0.83 | TRPM8 (0.40) | NR1H4RXRARXRBRXRGPPARA | |
| SCHEMBL2769947 | 0.82 | NR1H4 (0.39) | NR1H4RXRARXRBRXRGLNPEP | |
| SCHEMBL2770116 | 0.81 | KDM4E (0.40) | NR1H4RXRARXRBRXRGLNPEP | |
| SCHEMBL2771175 | 0.81 | NR1H4 (0.44) | NR1H4LNPEPPPARDMRGPRX4 | |
| SCHEMBL2770864 | 0.80 | NR1H4 (0.39) | NR1H4LNPEPP2RY1PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029547-B1 | FXR AGONISTS | LILLY CO ELI (US) | 2010-04-28 | — | — | EP | disclosed |