Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.44 |
| ▸ | ABL1 | P00519 | 10/20 | 0.44 |
| ▸ | BCR | P11274 | 10/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4832960 | 0.80 | ABL1 (0.72) | TRPV1ABL1BCRMAPK1MEN1 | |
| SCHEMBL16664932 | 0.77 | EGFR (0.42) | TRPV1MAPK1MEN1ALDH1A1TP53 | |
| SCHEMBL5202550 | 0.75 | ABL1 (0.53) | TRPV1ABL1BCRMAPK1MEN1 | |
| SCHEMBL6474257 | 0.73 | KMO (0.59) | ABL1TGFBR1HDAC1HDAC6FLT3 | |
| SCHEMBL27700674 | 0.70 | MTOR (0.37) | TRPV1ABL1TGFBR1HDAC1HDAC6 | |
| SCHEMBL4832759 | 0.67 | TRPV1 (0.87) | TRPV1ABL1BCR | |
| SCHEMBL4837497 | 0.67 | TRPV1 (0.76) | TRPV1ABL1BCRMAPK1MEN1 | |
| SCHEMBL8337311 | 0.67 | NPC1 (0.52) | TGFBR1HDAC1HDAC6FLT3MEN1 | |
| SCHEMBL5798983 | 0.67 | ABL1 (0.63) | TRPV1ABL1BCRMAPK1MEN1 | |
| SCHEMBL5797628 | 0.66 | TRPV1 (0.70) | TRPV1ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101035780-A | Substituted nitrogen-containing six-membered amino-heterocycles as vanilloid-1 receptor antagonists for treating pain | MERCK SHARP & DOHME (GB) | 2007-09-12 | — | — | CN | claimed |
| CN-101035780-A | Substituted nitrogen-containing six-membered amino-heterocycles as vanilloid-1 receptor antagonists for treating pain | MERCK SHARP & DOHME (GB) | 2007-09-12 | — | — | CN | disclosed |