Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 13/20 | 0.53 |
| ▸ | BCR | P11274 | 12/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4832960 | 0.82 | ABL1 (0.72) | ABL1BCRTRPV1USP2CYP1A2 | |
| SCHEMBL27700679 | 0.75 | TRPV1 (0.44) | ABL1BCRTRPV1USP2CYP1A2 | |
| SCHEMBL4097345 | 0.73 | USP2 (0.70) | USP2CYP1A2CYP2D6CYP2C19CLK4 | |
| SCHEMBL4837497 | 0.70 | TRPV1 (0.76) | ABL1BCRTRPV1USP2CYP1A2 | |
| SCHEMBL4832759 | 0.70 | TRPV1 (0.87) | ABL1BCRTRPV1 | |
| SCHEMBL5801083 | 0.70 | TRPV1 (0.69) | ABL1BCRTRPV1USP2CYP1A2 | |
| SCHEMBL5798983 | 0.70 | ABL1 (0.63) | ABL1BCRTRPV1USP2CYP1A2 | |
| SCHEMBL3400278 | 0.70 | ABL1 (0.80) | ABL1BCRMAPK1KDM4EMAPT | |
| SCHEMBL3399903 | 0.70 | ABL1 (1.00) | ABL1BCRMAPK1KDM4EMAPT | |
| SCHEMBL6473759 | 0.69 | ABL1 (0.62) | ABL1BCRTRPV1USP2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807418-A2 | SUBSTITUTED NITROGEN-CONTAINING HETEROCYCLES AS VANILLOID RECEPTOR LIGANDS AND THEIR USES AS MEDICAMENT | Amgen, Inc (US) | 2007-07-18 | — | — | EP | claimed |
| WO-2006047492-A2 | SUBSTITUTED NITROGEN-CONTAINING HETEROCYCLES AS VANILLOID RECEPTOR LIGANDS AND THEIR USES AS MEDICAMENT | AMGEN INC. (US) | 2006-05-04 | — | — | WO | claimed |