Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27310559 | 0.84 | KDM4E (0.53) | ALOX15HPGDSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7068027 | 0.83 | ALOX15 (0.58) | ALOX15HPGDLMNASMN1; SMN2SLC2A1 | |
| SCHEMBL8290938 | 0.81 | LMNA (0.58) | ALOX15HPGDLMNASMN1; SMN2SLC2A1 | |
| SCHEMBL3967007 | 0.80 | LMNA (0.57) | ALOX15HPGDLMNASMN1; SMN2SLC2A1 | |
| SCHEMBL2334699 | 0.78 | LMNA (0.59) | ALOX15HPGDLMNASMN1; SMN2SLC2A1 | |
| Chimanine A SCHEMBL8588818 | 0.78 | HPGD (0.59) | ALOX15HPGDLMNASMN1; SMN2SLC2A1 | |
| SCHEMBL27311485 | 0.78 | MEN1 (0.48) | HPGDSMN1; SMN2ALDH1A1KDM4EHTT | |
| SCHEMBL4390702 | 0.77 | LMNA (0.54) | ALOX15HPGDLMNASMN1; SMN2SLC2A1 | |
| SCHEMBL297225 | 0.76 | ALOX15 (1.00) | ALOX15HPGDLMNASMN1; SMN2SLC2A1 | |
| SCHEMBL20589656 | 0.76 | GAA (0.45) | ALOX15HPGDLMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101115742-B | Heterocycle derivatives as histone deacetylase (hdac) inhibitors | ANGELETTI P IST RICHERCHE BIO | 2011-06-22 | — | — | CN | disclosed |
| CN-101115742-A | Heterocycle derivatives as histone deacetylase (hdac) inhibitors | ANGELETTI P IST RICHERCHE BIO (IT) | 2008-01-30 | — | — | CN | disclosed |