Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | CENPE | Q02224 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27701899 | 0.89 | GPR139 (0.33) | GPR139RAB9AALDH1A1LMNAPKM | |
| SCHEMBL27701631 | 0.88 | HDAC1 (0.42) | HDAC1 | |
| SCHEMBL27701833 | 0.88 | HDAC1 (0.35) | HDAC1GRIN1GRIN2APLAUALDH1A1 | |
| SCHEMBL27722377 | 0.87 | GPR139 (0.37) | HDAC1GPR139RAB9AALDH1A1LMNA | |
| SCHEMBL27701832 | 0.86 | POLB (0.39) | HDAC1PLAUALDH1A1GAAMEP1B | |
| SCHEMBL27722187 | 0.85 | GPR139 (0.38) | HDAC1GPR139GRIN1GRIN2ARAB9A | |
| SCHEMBL27722270 | 0.84 | HDAC6 (0.39) | HDAC1PLAUMEP1B | |
| SCHEMBL27701639 | 0.81 | HDAC1 (0.35) | HDAC1GPR139 | |
| SCHEMBL27722260 | 0.81 | HDAC1 (0.36) | HDAC1PLAURAB9AGAANPC1 | |
| SCHEMBL27701908 | 0.81 | GRIN1 (0.33) | HDAC1GRIN1GRIN2ARAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101163703-B | Imidazo [1,2-A ] pyridine derivatives as Peptide Deformylase (PDF) inhibitors | NOVARTIS AG | 2010-12-15 | — | — | CN | disclosed |
| CN-101163703-A | Imidazo [1, 2-A ] pyridine derivatives as Peptide Deformylase (PDF) inhibitors | NOVARTIS AG (CH) | 2008-04-16 | — | — | CN | disclosed |