Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL564269 | 0.88 | TDP1 (0.49) | TDP1L3MBTL1GAAMAPK1MAOB | |
| SCHEMBL6813857 | 0.83 | TDP1 (0.44) | TDP1L3MBTL1GAAMAPK1MAOB | |
| SCHEMBL8559907 | 0.82 | TDP1 (0.49) | TDP1L3MBTL1GAAMAPK1MAOB | |
| SCHEMBL564671 | 0.80 | TDP1 (0.46) | TDP1L3MBTL1GAAMAPK1MAOB | |
| SCHEMBL7263592 | 0.75 | TDP1 (0.41) | TDP1MAPTALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL8564373 | 0.74 | TDP1 (0.53) | TDP1L3MBTL1GAAMAPK1MAOB | |
| SCHEMBL6814536 | 0.72 | TDP1 (0.50) | TDP1L3MBTL1GAAMAPK1MAOB | |
| SCHEMBL27702182 | 0.71 | TDP1 (0.46) | TDP1L3MBTL1GAAMAPK1MAOB | |
| SCHEMBL27815933 | 0.71 | TDP1 (0.49) | TDP1L3MBTL1GAAMAPK1MAOB | |
| SCHEMBL5259969 | 0.71 | SCN9A (0.40) | TDP1L3MBTL1GAAMAPK1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101160287-B | Pyridyl non-aromatic nitrogenated heterocyclic-1-carboxylate ester derivative | ASTELLAS PHARMA INC | 2011-08-03 | — | — | CN | disclosed |
| CN-101160287-A | Pyridyl non-aromatic nitrogenated heterocyclic-1-carboxylate ester derivative | ASTELLAS PHARMA INC (JP) | 2008-04-09 | — | — | CN | disclosed |