Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MRGPRX4 | Q96LA9 | 16/20 | 0.51 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.49 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.49 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL481193 | 0.92 | MAPT (0.53) | MAPTSMN1; SMN2CYP2C9CYP2C19TDP1 | |
| SCHEMBL31069853 | 0.84 | MAPT (0.72) | MAPTSMN1; SMN2CYP2C9CYP2C19TDP1 | |
| SCHEMBL480791 | 0.84 | MAPT (0.47) | MAPTSMN1; SMN2CYP2C9CYP2C19TDP1 | |
| SCHEMBL10245317 | 0.83 | MAPT (0.51) | MAPTSMN1; SMN2CYP2C9CYP2C19TDP1 | |
| SCHEMBL27686256 | 0.82 | GRM2 (0.49) | MAPTSMN1; SMN2CYP2C9CYP2C19TDP1 | |
| SCHEMBL481040 | 0.81 | SMN1; SMN2 (0.48) | MAPTSMN1; SMN2CYP2C9CYP2C19TDP1 | |
| SCHEMBL27686317 | 0.80 | GRM2 (0.47) | MAPTSMN1; SMN2CYP2C9CYP2C19TDP1 | |
| SCHEMBL27686260 | 0.80 | PTGER1 (0.47) | MAPTSMN1; SMN2CYP2C9CYP2C19TDP1 | |
| SCHEMBL481209 | 0.80 | MAPT (0.70) | MAPTSMN1; SMN2CYP2C9CYP2C19TDP1 | |
| SCHEMBL481438 | 0.79 | MRGPRX4 (0.57) | MAPTSMN1; SMN2CYP2C9CYP2C19TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101955470-A | Glutamate receptor potentiators | LILLY CO ELI | 2011-01-26 | — | — | CN | disclosed |
| CN-101061106-B | Glutamate receptor potentiators | LILLY CO ELI | 2010-09-29 | — | — | CN | disclosed |
| CN-101061106-A | Glutamate receptor potentiators | LILLY CO ELI (US) | 2007-10-24 | — | — | CN | disclosed |