Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSH | P09668 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27705286 | 0.79 | TDP1 (0.43) | TDP1GPR35TSHRSMN1; SMN2CTSB | |
| SCHEMBL27582725 | 0.78 | TDP1 (0.58) | TDP1GPR35TSHRSMN1; SMN2ERN1 | |
| SCHEMBL27705592 | 0.74 | TSHR (0.55) | TDP1GPR35TSHRSMN1; SMN2MEN1 | |
| SCHEMBL28765675 | 0.73 | GRM1 (0.33) | TSHRCYP3A4 | |
| SCHEMBL17368428 | 0.73 | ERN1 (0.59) | TDP1GPR35TSHRSMN1; SMN2ERN1 | |
| SCHEMBL1265167 | 0.72 | TDP1 (0.54) | TDP1GPR35TSHRSMN1; SMN2MEN1 | |
| SCHEMBL2651124 | 0.72 | TDP1 (0.54) | TDP1GPR35TSHRSMN1; SMN2CTSB | |
| SCHEMBL3167966 | 0.71 | ALDH1A1 (0.50) | TDP1GPR35TSHRSMN1; SMN2ERN1 | |
| SCHEMBL28755195 | 0.71 | TDP1 (0.52) | TDP1GPR35TSHRSMN1; SMN2CTSB | |
| SCHEMBL27781739 | 0.70 | ATM (0.51) | TDP1TSHRSMN1; SMN2GLAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101955470-B | Potentiators of glutamate receptors | LILLY CO ELI | 2012-06-13 | — | — | CN | disclosed |
| CN-101955470-A | Glutamate receptor potentiators | LILLY CO ELI | 2011-01-26 | — | — | CN | disclosed |
| CN-101061106-B | Glutamate receptor potentiators | LILLY CO ELI | 2010-09-29 | — | — | CN | disclosed |
| CN-101061106-A | Glutamate receptor potentiators | LILLY CO ELI (US) | 2007-10-24 | — | — | CN | disclosed |