Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 4/20 | 0.38 |
| ▸ | TYK2 | P29597 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | IL2 | P60568 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | ICOSLG | O75144 | 2/20 | 0.35 |
| ▸ | ICOS | Q9Y6W8 | 2/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27705333 | 0.91 | IL2 (0.40) | SORT1IL2RAB9ANPC1ALOX15 | |
| SCHEMBL5550895 | 0.76 | IL2 (0.43) | IL2RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL15395770 | 0.76 | IL2 (0.46) | SORT1IL2RAB9ANPC1ALOX15 | |
| SCHEMBL5554305 | 0.75 | IL2 (0.44) | IL2RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL5998369 | 0.74 | IL2 (0.45) | IL2RAB9AKMT2ANPC1ALOX15 | |
| SCHEMBL15395989 | 0.73 | IL2 (0.43) | IL2RAB9AKMT2ANPC1ALOX15 | |
| SCHEMBL15395956 | 0.72 | KDM4E (0.47) | IL2RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL5554346 | 0.72 | IL2 (0.52) | SORT1TYK2JAK2IL2KMT2A | |
| SCHEMBL5554247 | 0.72 | ALDH1A1 (0.48) | TYK2JAK2IL2RAB9AMEN1 | |
| SCHEMBL5556038 | 0.72 | ALDH1A1 (0.41) | IL2RAB9AMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101163478-A | Compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP (US) | 2008-04-16 | — | — | CN | claimed |
| CN-101163478-A | Compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP (US) | 2008-04-16 | — | — | CN | disclosed |