Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 8/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | P4HB | P07237 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5091881 | 0.82 | ACHE (0.46) | BACE1GBA1 | |
| SCHEMBL5091955 | 0.81 | DRD2 (0.49) | CYP11B1CYP11B2 | |
| SCHEMBL5094873 | 0.80 | CYP1A2 (0.43) | CYP11B1CYP11B2ALDH1A1MEN1CYP17A1 | |
| SCHEMBL27706491 | 0.79 | CYP11B1 (0.38) | CYP11B1CYP11B2CYP17A1CYP19A1BACE1 | |
| SCHEMBL5096924 | 0.79 | PIK3CA (0.43) | CYP11B1CYP11B2 | |
| SCHEMBL28765769 | 0.79 | — | — | |
| SCHEMBL5091017 | 0.77 | ABCB1 (0.43) | CYP11B1CYP11B2KMT2AMEN1CASP3 | |
| SCHEMBL5103707 | 0.77 | ACHE (0.38) | CYP11B1CYP11B2BACE1TNIKKDM4E | |
| SCHEMBL4516385 | 0.76 | CYP11B1 (0.41) | CYP11B1CYP11B2MEN1CYP17A1CYP19A1 | |
| SCHEMBL5094857 | 0.76 | PARP1 (0.39) | CYP11B1CYP11B2ALDH1A1BACE1TNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128458-A | Tricyclic delta opioid modulators | JANSSEN PHARMACEUTICA NV (BE) | 2008-02-20 | — | — | CN | claimed |
| CN-101128458-A | Tricyclic delta opioid modulators | JANSSEN PHARMACEUTICA NV (BE) | 2008-02-20 | — | — | CN | disclosed |