Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 2/20 | 0.40 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.40 |
| ▸ | BLK | P51451 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1136433 | 0.88 | BTK (0.57) | MAPTALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL1136434 | 0.88 | BTK (0.57) | MAPTALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL1136423 | 0.85 | CHEK2 (0.52) | MAPTALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL27755013 | 0.84 | BTK (0.45) | MAPTALDH1A1LMNAHPGDHTT | |
| SCHEMBL1136425 | 0.83 | BTK (0.52) | MAPTALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL1136426 | 0.83 | BTK (0.52) | MAPTALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL1136409 | 0.83 | BLK (0.57) | MAPTALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL1136378 | 0.82 | MMP2 (0.53) | MAPTALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL1136400 | 0.82 | BTK (0.53) | BTKRAB9A | |
| SCHEMBL1136399 | 0.82 | BTK (0.53) | BTKRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101208338-B | Azabenzimidazole derivatives, their manufacture and use as anti-cancer agents | HOFFMANN LA ROCHE | 2010-12-29 | — | — | CN | claimed |
| CN-101208338-A | Azabenzimidazole derivatives, their manufacture and use as anti-cancer agents | HOFFMANN LA ROCHE (CH) | 2008-06-25 | — | — | CN | claimed |
| CN-101208338-B | Azabenzimidazole derivatives, their manufacture and use as anti-cancer agents | HOFFMANN LA ROCHE | 2010-12-29 | — | — | CN | disclosed |
| CN-101208338-A | Azabenzimidazole derivatives, their manufacture and use as anti-cancer agents | HOFFMANN LA ROCHE (CH) | 2008-06-25 | — | — | CN | disclosed |