Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 3/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.49 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1267188 | 0.80 | MRGPRX4 (0.49) | CDC7ROCK2MAP4K4PIM1PRKACA | |
| SCHEMBL1267975 | 0.73 | CSF1R (0.58) | CDC7ROCK2MAP4K4PIM1PRKACA | |
| SCHEMBL1267798 | 0.72 | MAOB (0.45) | CDC7ROCK2MAP4K4PIM1PRKACA | |
| SCHEMBL22043993 | 0.69 | ROCK2 (0.54) | CDC7ROCK2MAP4K4PIM1PRKACA | |
| SCHEMBL3386630 | 0.67 | CDC7 (0.52) | CDC7ROCK2MAP4K4PIM1PRKACA | |
| SCHEMBL8940229 | 0.66 | CDC7 (1.00) | CDC7ROCK2MAP4K4PIM1PRKACA | |
| SCHEMBL3608840 | 0.66 | MAP4K4 (0.59) | CDC7ROCK2MAP4K4PIM1PRKACA | |
| SCHEMBL12252093 | 0.66 | MAP2K1 (0.46) | CDC7ROCK2PIM1PRKACACDK2 | |
| SCHEMBL414181 | 0.65 | BRAF (0.56) | MAPTHTTPPIA | |
| SCHEMBL27708248 | 0.64 | CDC7 (0.42) | CDC7ROCK2MAP4K4PIM1PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101223169-A | Pyrrolo [2, 3-b ] pyridine derivative protein kinase inhibitors | PLEXXIKON INC (US) | 2008-07-16 | — | — | CN | disclosed |