Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclohexylamine SCHEMBL28744222 | 1.00 | THRB (0.44) | THRBMEN1KMT2AALDH1A1MMP1 | |
| Cyclohexylamine SCHEMBL28087254 | 0.92 | THRB (0.44) | THRBMEN1KMT2AALDH1A1MMP1 | |
| Cyclohexylamine SCHEMBL11648185 | 0.92 | THRB (0.44) | THRBMEN1KMT2AALDH1A1MMP1 | |
| Cyclohexylamine SCHEMBL5159626 | 0.92 | — | — | |
| SCHEMBL23379885 | 0.92 | THRB (0.50) | THRBMEN1KMT2AALDH1A1 | |
| SCHEMBL21416372 | 0.92 | THRB (0.50) | THRBMEN1KMT2AALDH1A1 | |
| SCHEMBL20858602 | 0.92 | THRB (0.50) | THRBMEN1KMT2AALDH1A1 | |
| SCHEMBL24893550 | 0.92 | THRB (0.50) | THRBMEN1KMT2AALDH1A1 | |
| SCHEMBL20726193 | 0.92 | THRB (0.50) | THRBMEN1KMT2AALDH1A1 | |
| SCHEMBL20830445 | 0.92 | THRB (0.50) | THRBMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101171268-B | Catalyst for olefin polymerization, method for producing catalyst for olefin polymerization, and method for storing catalyst for olefin polymerization | JAPAN POLYPROPYLENE CORP | 2011-01-12 | — | — | CN | disclosed |
| CN-101171268-A | Catalyst for olefin polymerization, method for producing catalyst for olefin polymerization, and method for storing catalyst for olefin polymerization | JAPAN POLYPROPYLENE CORP (JP) | 2008-04-30 | — | — | CN | disclosed |