Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 5/20 | 0.44 |
| ▸ | MMP2 | P08253 | 5/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27709775 | 0.96 | HTT (0.63) | HTTTDP1HDAC3HDAC4HDAC1 | |
| SCHEMBL27689983 | 0.89 | HTT (0.50) | HTTTDP1HDAC3HDAC4HDAC1 | |
| Guanidine SCHEMBL27709641 | 0.82 | HTT (0.59) | HTTTDP1HDAC3HDAC4HDAC1 | |
| SCHEMBL27709604 | 0.82 | HTT (0.59) | HTTTDP1HDAC3HDAC4HDAC1 | |
| Guanidine SCHEMBL27709634 | 0.79 | HTT (0.68) | HTTTDP1HDAC3HDAC4HDAC1 | |
| SCHEMBL1949534 | 0.78 | HTT (0.70) | HTTTDP1HDAC3HDAC4HDAC1 | |
| SCHEMBL1949533 | 0.78 | HTT (0.70) | HTTTDP1HDAC3HDAC4HDAC1 | |
| SCHEMBL27689874 | 0.77 | HTT (0.64) | HTTTDP1HDAC3HDAC4HDAC1 | |
| Hydrochloric Acid SCHEMBL5427446 | 0.76 | HTT (0.68) | HTTTDP1HDAC3HDAC4HDAC1 | |
| Hydrochloric Acid SCHEMBL5427447 | 0.76 | HTT (0.68) | HTTTDP1HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101111475-A | Antiviral compounds and methods | BIOTRON LTD (AU) | 2008-01-23 | — | — | CN | disclosed |