Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.82 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.81 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.81 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.81 |
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | MEN1 | O00255 | 4/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.70 |
| ▸ | HTR6 | P50406 | 2/20 | 0.66 |
| ▸ | GAA | P10253 | 2/20 | 0.63 |
| ▸ | DCTPP1 | Q9H773 | 3/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1842281 | 0.90 | MAPT (1.00) | MAPTALDH1A1NPSR1CYP2C9CYP2C19 | |
| SCHEMBL2481065 | 0.90 | MAPT (1.00) | MAPTALDH1A1NPSR1CYP2C9CYP2C19 | |
| SCHEMBL27690606 | 0.86 | MAPT (1.00) | MAPTALDH1A1NPSR1CYP2C9CYP2C19 | |
| SCHEMBL1846393 | 0.86 | HTR6 (0.67) | MAPTALDH1A1NPSR1CYP2C9CYP2C19 | |
| SCHEMBL1840598 | 0.86 | MAPT (0.71) | MAPTALDH1A1NPSR1CYP2C9CYP2C19 | |
| SCHEMBL7937233 | 0.84 | MAPT (0.78) | MAPTALDH1A1NPSR1CYP2C9CYP2C19 | |
| SCHEMBL7939694 | 0.82 | MAPT (0.81) | MAPTALDH1A1NPSR1CYP2C9CYP2C19 | |
| SCHEMBL16299036 | 0.82 | MAPT (0.67) | MAPTALDH1A1NPSR1CYP2C9CYP2C19 | |
| SCHEMBL27690607 | 0.82 | MAPT (1.00) | MAPTALDH1A1NPSR1CYP2C9CYP2C19 | |
| SCHEMBL2486196 | 0.81 | ALDH1A1 (0.55) | MAPTALDH1A1NPSR1CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101133042-A | Nitro-substituted phenyl-piperazine compounds, their preparation and use in medicaments | ESTEVE LABOR DR (ES) | 2008-02-27 | — | — | CN | claimed |
| CN-101563106-A | Combination of nmda- receptor ligand and a compound with 5-HT6 receptor affinity | ESTEVE LABOR DR (ES) | 2009-10-21 | — | — | CN | disclosed |
| CN-101500611-A | Combination of a cholinesterase inhibitor and a compound with 5-HT6 receptor affinity | ESTEVE LABOR DR (ES) | 2009-08-05 | — | — | CN | disclosed |
| CN-101133042-A | Nitro-substituted phenyl-piperazine compounds, their preparation and use in medicaments | ESTEVE LABOR DR (ES) | 2008-02-27 | — | — | CN | disclosed |