Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 5/20 | 0.36 |
| ▸ | PLAU | P00749 | 4/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MITF | O75030 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3766982 | 0.81 | LMNA (0.43) | ELANEPLAUF2KLKB1ALDH1A1 | |
| SCHEMBL21819552 | 0.75 | ALDH1A1 (0.35) | ELANEPLAUF2KLKB1ALDH1A1 | |
| SCHEMBL21995832 | 0.74 | ELANE (0.40) | ELANEPLAUF2KLKB1ALDH1A1 | |
| SCHEMBL13412138 | 0.73 | CYP4F2 (0.43) | ELANEPLAUF2KLKB1ALDH1A1 | |
| SCHEMBL18614491 | 0.73 | ELANE (0.33) | ELANEPLAUF2KLKB1ALDH1A1 | |
| SCHEMBL18622410 | 0.73 | ELANE (0.39) | ELANEPLAUF2KLKB1ALDH1A1 | |
| SCHEMBL673370 | 0.70 | ALDH1A1 (0.35) | ELANEPLAUF2KLKB1ALDH1A1 | |
| SCHEMBL1582031 | 0.70 | KIT (0.43) | ELANEPLAUF2KLKB1ALDH1A1 | |
| SCHEMBL20519689 | 0.70 | MAP4K4 (0.38) | ELANEPLAUF2KLKB1ALDH1A1 | |
| SCHEMBL20520051 | 0.70 | ELANE (0.37) | ELANEPLAUF2KLKB1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101018780-B | Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors | PFIZER | 2012-01-11 | — | — | CN | disclosed |
| CN-101018780-A | Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors | AGOURON PHARMA (US) | 2007-08-15 | — | — | CN | disclosed |