Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 9/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 8/20 | 0.56 |
| ▸ | CHRNA7 | P36544 | 8/20 | 0.51 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27732325 | 1.00 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRNA7CYP2A6MEN1 | |
| SCHEMBL7008708 | 0.83 | CHRNB2 (0.67) | CHRNB2CHRNA4CHRNA7CYP2A6MEN1 | |
| SCHEMBL27467551 | 0.83 | — | — | |
| SCHEMBL8565971 | 0.80 | SCN10A (0.38) | CHRNB2CHRNA4CHRNA7CYP2C19CYP1A2 | |
| SCHEMBL6142909 | 0.80 | GBA1 (0.46) | CYP2A6MEN1CYP2D6CYP2C19KMT2A | |
| SCHEMBL5739415 | 0.80 | GBA1 (0.46) | CYP2A6MEN1CYP2D6CYP2C19KMT2A | |
| Hydrochloric Acid SCHEMBL16321069 | 0.79 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRNA7CYP2A6MEN1 | |
| SCHEMBL25771779 | 0.76 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRNA7CYP2A6MEN1 | |
| SCHEMBL7591667 | 0.76 | CHRNB2 (0.47) | CHRNB2CHRNA4CHRNA7CYP2A6MEN1 | |
| SCHEMBL7591664 | 0.76 | CHRNB2 (0.47) | CHRNB2CHRNA4CHRNA7CYP2A6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101184750-A | Pyrimidine compounds as insulin-like growth factor I inhibitors | ASTRAZENECA UK LTD (SE) | 2008-05-21 | — | — | CN | disclosed |