Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTO1 | P78417 | 5/20 | 0.60 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.52 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | NPY1R | P25929 | 1/20 | 0.51 |
| ▸ | NPY2R | P49146 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4443052 | 0.88 | KDR (0.71) | GSTO1KDRKCNJ5KCNJ3SMN1; SMN2 | |
| SCHEMBL9728728 | 0.88 | KDR (0.54) | GSTO1KDRKCNJ5KCNJ3SMN1; SMN2 | |
| SCHEMBL4556067 | 0.83 | KDR (0.75) | KDRSMN1; SMN2HTTLMNAMEN1 | |
| SCHEMBL5248618 | 0.82 | KDR (0.58) | KDRKCNJ5KCNJ3SMN1; SMN2HTT | |
| SCHEMBL11787916 | 0.82 | KDR (0.58) | KDRKCNJ5KCNJ3SMN1; SMN2HTT | |
| SCHEMBL4006280 | 0.81 | GRM4 (0.57) | GSTO1KDRKCNJ5KCNJ3SMN1; SMN2 | |
| SCHEMBL28875490 | 0.81 | KDR (0.57) | KDRSMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL5742985 | 0.81 | KDR (0.57) | KDRSMN1; SMN2HTTLMNAMAPT | |
| Fluoride SCHEMBL11787921 | 0.81 | KDR (0.57) | KDRKCNJ5KCNJ3HTTMEN1 | |
| SCHEMBL28882268 | 0.80 | GSTO1 (0.59) | GSTO1KDRKCNJ5KCNJ3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128427-B | Heterocyclic compounds as ccr2b antagonists | ASTRAZENECA AB | 2013-03-27 | — | — | CN | disclosed |
| CN-101128427-A | Heterocyclic compounds as ccr2b antagonists | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |