Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.34 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2769947 | 0.93 | NR1H4 (0.39) | NR1H4TRPM8LNPEP | |
| SCHEMBL2775280 | 0.91 | NR1H4 (0.40) | NR1H4LNPEPPPARDP2RY1 | |
| SCHEMBL2771579 | 0.88 | NR1H4 (0.40) | NR1H4TRPM8LNPEPPPARD | |
| SCHEMBL2771162 | 0.84 | NR1H4 (0.61) | NR1H4MRGPRX4 | |
| SCHEMBL2770975 | 0.82 | NR1H4 (0.44) | NR1H4MRGPRX4PRKAG1PRKAA2PRKAB1 | |
| SCHEMBL2771301 | 0.81 | NR1H4 (0.43) | NR1H4MRGPRX4PRKAG1PRKAA2PRKAB1 | |
| SCHEMBL2772913 | 0.81 | NR1H4 (0.62) | NR1H4 | |
| SCHEMBL2771175 | 0.81 | NR1H4 (0.44) | NR1H4MRGPRX4PRKAG1PRKAA2PRKAB1 | |
| SCHEMBL2772915 | 0.81 | NR1H4 (0.62) | NR1H4 | |
| SCHEMBL2770877 | 0.81 | NR1H4 (0.42) | NR1H4PPARGLNPEPPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029547-B1 | FXR AGONISTS | LILLY CO ELI (US) | 2010-04-28 | — | — | EP | disclosed |