Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.32 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 9/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2771579 | 0.93 | NR1H4 (0.40) | NR1H4FFAR1PTGDR2LNPEPPPARD | |
| SCHEMBL2771304 | 0.91 | NR1H4 (0.43) | NR1H4LNPEPPPARDP2RY1 | |
| SCHEMBL2769947 | 0.88 | NR1H4 (0.39) | NR1H4LNPEP | |
| SCHEMBL2769946 | 0.84 | NR1H4 (0.50) | NR1H4FFAR1PPARD | |
| SCHEMBL2775274 | 0.82 | NR1H4 (0.40) | NR1H4FFAR1PTGDR2LNPEPPPARD | |
| SCHEMBL2771573 | 0.79 | NR1H4 (0.40) | NR1H4FFAR1PTGDR2LNPEPPPARD | |
| SCHEMBL2772145 | 0.78 | NR1H4 (0.51) | NR1H4FFAR1PPARD | |
| SCHEMBL2770975 | 0.77 | NR1H4 (0.44) | NR1H4PPARA | |
| SCHEMBL2773384 | 0.76 | TRPM8 (0.40) | NR1H4PPARA | |
| SCHEMBL2770877 | 0.75 | NR1H4 (0.42) | NR1H4LNPEPPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029547-B1 | FXR AGONISTS | LILLY CO ELI (US) | 2010-04-28 | — | — | EP | disclosed |