Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 2/20 | 0.34 |
| ▸ | ACHE | P22303 | 5/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.32 |
| ▸ | MLYCD | O95822 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27713654 | 0.87 | SMN1; SMN2 (0.39) | HCAR3MLYCDMEN1ALDH1A1POLB | |
| SCHEMBL27746608 | 0.78 | MAPK1 (0.33) | HCAR3MEN1ALDH1A1POLBKMT2A | |
| SCHEMBL27693806 | 0.77 | AGBL2 (0.34) | ACHEPIK3CDMLYCDMEN1ALDH1A1 | |
| SCHEMBL27713651 | 0.73 | POLB (0.38) | MEN1ALDH1A1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL27767624 | 0.70 | HTT (0.42) | — | |
| SCHEMBL27746611 | 0.68 | MEN1 (0.37) | MEN1ALDH1A1POLBKMT2AGAA | |
| SCHEMBL1447802 | 0.67 | MLYCD (0.33) | MLYCD | |
| SCHEMBL5244620 | 0.67 | MLYCD (0.33) | MLYCD | |
| SCHEMBL1447958 | 0.66 | CYP1A2 (0.36) | MEN1ALDH1A1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL27701545 | 0.61 | KCNH2 (0.34) | HCAR3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101273031-A | Imidazolyl-pyrimidine compounds for use in the treatment of proliferative disorders | ASTRAZENECA AB (SE) | 2008-09-24 | — | — | CN | disclosed |
| CN-101115752-A | 4- (4- (imidazol-4-yl) pyrimidin-2-ylamino) benzamides as cdk inhibitors | ASTRAZENECA AB (SE) | 2008-01-30 | — | — | CN | disclosed |