Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 19/20 | 0.70 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27713822 | 0.84 | FLT3 (0.69) | FLT3PDGFRBKIT | |
| SCHEMBL27713847 | 0.82 | FLT3 (1.00) | FLT3PDGFRBKIT | |
| SCHEMBL13956330 | 0.82 | FLT3 (1.00) | FLT3PDGFRBKIT | |
| SCHEMBL27734330 | 0.81 | FLT3 (0.67) | FLT3PDGFRBKITEGFRERBB2 | |
| SCHEMBL28775244 | 0.81 | FLT3 (0.66) | FLT3PDGFRBKITEGFRERBB2 | |
| SCHEMBL5921852 | 0.81 | FLT3 (0.78) | FLT3PDGFRBKIT | |
| SCHEMBL5921851 | 0.81 | FLT3 (0.78) | FLT3PDGFRBKIT | |
| SCHEMBL13955966 | 0.81 | FLT3 (1.00) | FLT3PDGFRBKIT | |
| SCHEMBL27734124 | 0.80 | FLT3 (0.67) | FLT3PDGFRBKITEGFRERBB2 | |
| SCHEMBL4960587 | 0.80 | FLT3 (0.78) | FLT3PDGFRBKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101242843-A | Aminopyrimidines as kinase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2008-08-13 | — | — | CN | disclosed |