Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 12/20 | 0.76 |
| ▸ | DDR2 | Q16832 | 5/20 | 0.62 |
| ▸ | DDR1 | Q08345 | 4/20 | 0.61 |
| ▸ | CSF1R | P07333 | 2/20 | 0.59 |
| ▸ | KIT | P10721 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | RAF1 | P04049 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | BTK | Q06187 | 1/20 | 0.53 |
| ▸ | TEK | Q02763 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5000861 | 0.85 | BRAF (0.76) | BRAFDDR2DDR1CSF1RKIT | |
| SCHEMBL5897754 | 0.79 | BRAF (1.00) | BRAFCSF1RKITKDRRAF1 | |
| SCHEMBL17208690 | 0.78 | CSF1R (0.66) | BRAFDDR2DDR1CSF1RKIT | |
| SCHEMBL5004469 | 0.78 | BRAF (0.83) | BRAFCSF1RKITKDRRAF1 | |
| SCHEMBL6487130 | 0.78 | BRAF (0.72) | BRAFDDR2CSF1RKITKDR | |
| SCHEMBL7840187 | 0.77 | BRAF (0.91) | BRAFCSF1RKITKDRRAF1 | |
| SCHEMBL19073209 | 0.77 | BRAF (0.73) | BRAFCSF1RKITLCK | |
| SCHEMBL6487127 | 0.77 | BRAF (0.70) | BRAFDDR2CSF1RKITKDR | |
| SCHEMBL22065317 | 0.76 | BRAF (0.72) | BRAFCSF1RKITLCK | |
| SCHEMBL15127735 | 0.76 | BRAF (0.72) | BRAFCSF1RKITKDRRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101080396-A | Quinoxalines as B Raf inhibitors | ASTRAZENECA AB (SE) | 2007-11-28 | — | — | CN | disclosed |