SCHEMBL27715422

SCHEMBL27715422

Cc1onc(-c2ccccc2Br)c1C(=O)c1c[nH]c(CC(=O)O)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GHSR Q92847 1/20 0.46
SMN1; SMN2 Q16637 2/20 0.44
HTT P42858 1/20 0.44
CACNA1F O60840 1/20 0.42
CACNA1D Q01668 1/20 0.42
CACNA1S Q13698 1/20 0.42
CACNA1C Q13936 1/20 0.42
MAPT P10636 6/20 0.41
ALDH1A1 P00352 4/20 0.41
LMNA P02545 3/20 0.41
GAA P10253 1/20 0.41
CYP2C19 P33261 1/20 0.41
GPBAR1 Q8TDU6 2/20 0.40
POLB P06746 1/20 0.39
HPGD P15428 1/20 0.39
HSD17B10 Q99714 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
RXFP1 Q9HBX9 1/20 0.39
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28771249 0.88 CYP2C19 (0.56) MAPTALDH1A1LMNAGAACYP2C19
SCHEMBL28771214 0.88 GPBAR1 (0.46) SMN1; SMN2HTTMAPTALDH1A1LMNA
SCHEMBL27715603 0.86 HTT (0.56) SMN1; SMN2HTTMAPTALDH1A1LMNA
SCHEMBL3977232 0.84 SMN1; SMN2 (0.50) GHSRSMN1; SMN2HTTCACNA1FCACNA1D
SCHEMBL27715527 0.83 HTT (0.47) SMN1; SMN2HTTCACNA1FCACNA1DCACNA1S
SCHEMBL27715415 0.82 HTT (0.47) SMN1; SMN2HTTCACNA1FCACNA1DCACNA1S
SCHEMBL3975800 0.79 ALDH1A1 (0.49) GHSRSMN1; SMN2HTTCACNA1FCACNA1D
SCHEMBL27715421 0.79 GHSR (0.44) GHSRSMN1; SMN2HTTCACNA1FCACNA1D
SCHEMBL27736172 0.79 SMN1; SMN2 (0.47) SMN1; SMN2HTTALDH1A1LMNAGAA
SCHEMBL27715424 0.79 GPBAR1 (0.48) GHSRSMN1; SMN2HTTMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101263139-A Isoxazolo derivatives as GABA A alpha5 inverse agonists HOFFMANN LA ROCHE (CH) 2008-09-10 CN disclosed