Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | BLM | P54132 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | GMNN | O75496 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.60 |
| ▸ | THPO | P40225 | 1/20 | 0.60 |
| ▸ | MTOR | P42345 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | HBB | P68871 | 1/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.60 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.57 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acadesine SCHEMBL5053863 | 0.80 | KDM4E (1.00) | TP53KDM4ETDP1MAPTALDH1A1 | |
| Acadesine SCHEMBL14520658 | 0.80 | KDM4E (1.00) | TP53KDM4ETDP1MAPTALDH1A1 | |
| Acadesine SCHEMBL7141001 | 0.80 | KDM4E (1.00) | TP53KDM4ETDP1MAPTALDH1A1 | |
| Acadesine SCHEMBL6113798 | 0.80 | KDM4E (1.00) | TP53KDM4ETDP1MAPTALDH1A1 | |
| SCHEMBL6934040 | 0.80 | TP53 (0.62) | TP53KDM4ETDP1MAPTALDH1A1 | |
| Acadesine SCHEMBL10017743 | 0.80 | KDM4E (1.00) | TP53KDM4ETDP1MAPTALDH1A1 | |
| Acadesine SCHEMBL2394079 | 0.80 | KDM4E (1.00) | TP53KDM4ETDP1MAPTALDH1A1 | |
| Acadesine SCHEMBL2631614 | 0.80 | KDM4E (1.00) | TP53KDM4ETDP1MAPTALDH1A1 | |
| SCHEMBL9619994 | 0.80 | TP53 (0.62) | TP53KDM4ETDP1MAPTALDH1A1 | |
| SCHEMBL4738954 | 0.80 | KDM4E (0.81) | TP53KDM4ETDP1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101243102-A | Improvements to analogous compounds of 6-thioguanosine triphosphate, their use in medical fields and processes for their preparation | GIULIANI INT LTD (IE) | 2008-08-13 | — | — | CN | disclosed |