Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.71 |
| ▸ | CA9 | Q16790 | 2/20 | 0.71 |
| ▸ | CA1 | P00915 | 1/20 | 0.71 |
| ▸ | CA2 | P00918 | 1/20 | 0.71 |
| ▸ | ERN1 | O75460 | 3/20 | 0.64 |
| ▸ | PLAU | P00749 | 4/20 | 0.63 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.60 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.60 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.60 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | CDK8 | P49336 | 1/20 | 0.59 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.58 |
| ▸ | FNTA | P49354 | 1/20 | 0.57 |
| ▸ | FNTB | P49356 | 1/20 | 0.57 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.57 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.56 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.56 |
| ▸ | PLAT | P00750 | 2/20 | 0.56 |
| ▸ | PLG | P00747 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL67941 | 0.98 | CA12 (0.68) | CA12CA9CA1CA2ERN1 | |
| SCHEMBL1221576 | 0.96 | TSHR (0.67) | CA12CA9CA1CA2ERN1 | |
| SCHEMBL29410906 | 0.96 | TSHR (0.67) | CA12CA9CA1CA2ERN1 | |
| Hydrochloric Acid SCHEMBL29506745 | 0.94 | CA12 (0.65) | CA12CA9CA1CA2ERN1 | |
| SCHEMBL68931 | 0.94 | CA12 (0.69) | CA12CA9CA1CA2ERN1 | |
| SCHEMBL3359577 | 0.94 | CA12 (0.65) | CA12CA9CA1CA2ERN1 | |
| SCHEMBL30443216 | 0.91 | CA12 (0.66) | CA12CA9CA1CA2ERN1 | |
| SCHEMBL514 | 0.91 | CA12 (0.66) | CA12CA9CA1CA2ERN1 | |
| SCHEMBL1661764 | 0.91 | CA12 (0.66) | CA12CA9CA1CA2ERN1 | |
| SCHEMBL17348229 | 0.90 | CA12 (0.60) | CA12CA9CA1CA2ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103249735-B | Tricyclic compounds and methods of making and using the same | ZAFGEN CORP. (US) | 2016-04-06 | — | — | CN | disclosed |
| CN-103249735-A | Tricyclic compounds and methods of making and using the same | ZAFGEN CORP | 2013-08-14 | — | — | CN | disclosed |
| CN-101228146-A | Benzofuran derivatives with therapeutic activities | PHARMOS CORP (US) | 2008-07-23 | — | — | CN | disclosed |