Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 9/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.44 |
| ▸ | RXRA | P19793 | 2/20 | 0.41 |
| ▸ | RXRB | P28702 | 2/20 | 0.41 |
| ▸ | RXRG | P48443 | 2/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | BCL2 | P10415 | 2/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2772150 | 0.92 | MRGPRX4 (0.52) | NR1H4MRGPRX4BCL2MCL1 | |
| SCHEMBL2773707 | 0.91 | NR1H4 (0.60) | NR1H4MRGPRX4RXRARXRBTRPM8 | |
| SCHEMBL2775269 | 0.85 | NR1H4 (0.47) | NR1H4MRGPRX4RXRARXRBRXRG | |
| SCHEMBL498302 | 0.84 | NR1H4 (0.60) | NR1H4MRGPRX4RXRARXRB | |
| SCHEMBL2772065 | 0.84 | NR1H4 (0.46) | NR1H4MRGPRX4RXRARXRBRXRG | |
| SCHEMBL2772217 | 0.84 | NR1H4 (0.57) | NR1H4MRGPRX4RXRARXRB | |
| SCHEMBL2774437 | 0.84 | NR1H4 (0.50) | NR1H4MRGPRX4RXRARXRBRXRG | |
| SCHEMBL2770721 | 0.83 | NR1H4 (0.45) | NR1H4MRGPRX4PPARA | |
| SCHEMBL2771180 | 0.83 | NR1H4 (0.63) | NR1H4MRGPRX4BCL2MCL1 | |
| SCHEMBL2770584 | 0.83 | NR1H4 (0.54) | NR1H4MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029547-B1 | FXR AGONISTS | LILLY CO ELI (US) | 2010-04-28 | — | — | EP | disclosed |