Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 11/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | BCL2 | P10415 | 2/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.39 |
| ▸ | LIFR | P42702 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2775269 | 0.94 | NR1H4 (0.47) | NR1H4MRGPRX4RXRARXRBRXRG | |
| SCHEMBL2775206 | 0.93 | MRGPRX4 (0.48) | NR1H4MRGPRX4PPARABCL2MCL1 | |
| SCHEMBL2770721 | 0.90 | NR1H4 (0.45) | NR1H4MRGPRX4PPARALIFR | |
| SCHEMBL2773814 | 0.86 | MRGPRX4 (0.50) | NR1H4MRGPRX4BCL2MCL1 | |
| SCHEMBL2833139 | 0.85 | NR1H4 (0.44) | NR1H4MRGPRX4RXRARXRBRXRG | |
| SCHEMBL2772063 | 0.84 | PPARA (0.43) | NR1H4MRGPRX4RXRARXRBRXRG | |
| SCHEMBL2771625 | 0.84 | NR1H4 (0.47) | NR1H4MRGPRX4RXRARXRBRXRG | |
| SCHEMBL2770436 | 0.83 | MRGPRX4 (0.48) | NR1H4MRGPRX4BCL2MCL1LIFR | |
| SCHEMBL498302 | 0.81 | NR1H4 (0.60) | NR1H4MRGPRX4RXRARXRBLIFR | |
| SCHEMBL2773707 | 0.81 | NR1H4 (0.60) | NR1H4MRGPRX4RXRARXRBLIFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029547-B1 | FXR AGONISTS | LILLY CO ELI (US) | 2010-04-28 | — | — | EP | disclosed |