Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.40 |
| ▸ | PPID | Q08752 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10413532 | 0.81 | MAPK14 (0.59) | SMN1; SMN2MAPK14MEN1KMT2AS1PR1 | |
| SCHEMBL20553301 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2MEN1KMT2ATSHRS1PR1 | |
| SCHEMBL4128170 | 0.77 | ALDH1A1 (0.36) | SMN1; SMN2MAPK14MEN1KMT2AS1PR1 | |
| SCHEMBL9877095 | 0.75 | SMN1; SMN2 (0.76) | SMN1; SMN2MEN1KMT2ATSHRS1PR1 | |
| SCHEMBL2896401 | 0.74 | ALDH1A1 (0.66) | SMN1; SMN2MEN1KMT2AS1PR1ALDH1A1 | |
| SCHEMBL9878548 | 0.74 | SMN1; SMN2 (0.67) | SMN1; SMN2MEN1KMT2ATSHRS1PR1 | |
| SCHEMBL10413222 | 0.74 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPK14MEN1KMT2ATSHR | |
| SCHEMBL9877800 | 0.73 | SMN1; SMN2 (0.58) | SMN1; SMN2MAPK14MEN1KMT2ATSHR | |
| SCHEMBL4125843 | 0.72 | MAPK14 (0.37) | MAPK14CDC7MAPK1 | |
| SCHEMBL27716481 | 0.72 | MAPK14 (0.48) | SMN1; SMN2MAPK14MEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101282960-A | RAF inhibitor compounds and methods | GENENTECH INC (US) | 2008-10-08 | — | — | CN | disclosed |