Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 3/20 | 0.49 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.49 |
| ▸ | HTR3B | O95264 | 2/20 | 0.49 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.49 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9202114 | 0.84 | HRH4 (0.59) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL28650816 | 0.80 | KMT2A (0.36) | KMT2A | |
| SCHEMBL15956636 | 0.78 | HTR3A (0.53) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL3878600 | 0.77 | HTT (0.44) | KMT2AKDM4E | |
| SCHEMBL2336863 | 0.76 | HRH4 (0.66) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Aethimidinum SCHEMBL29352989 | 0.75 | CASP1 (0.50) | HRH4NPSR1KMT2A | |
| SCHEMBL13525376 | 0.74 | HTR3A (0.57) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL4806161 | 0.73 | HTR3A (0.51) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL1024211 | 0.73 | HRH4 (0.70) | HRH4KMT2A | |
| SCHEMBL3167172 | 0.73 | HTR3A (0.59) | HTR3AHTR3EHTR3BHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101277951-A | 2-aminopyrimidine derivatives as modulators of the histamine H4 receptor activity | PALAU PHARMA SA (ES) | 2008-10-01 | — | — | CN | disclosed |